During the Second Robotech War, the Robotech Masters sought to recover the hidden Protoculture Matrix. It contents, the Invid Flower of Life, had already begun to break through the containment unit of the SDF-1 wreckage. In an act of desperation, Zor Prime blew up a Tirolian Mothership above the three giant burial mounds in an attempt to wipe out the flowers. However, the attempt backfired as the blast only succeeded in spreading the spores around the Earth.
Within a year, the Invid Sensor Nebula pinpointed the growth of the Flower of Life on Earth and the Invid Invasion began. The Army of the Southern Cross and other Earth forces, already weakened by war with the Robotech Masters, were no match for the Invid. Reflex Point soon fell under the control of the Invid Queen - also known as the Regess.
After years of failed attempts to liberate the Earth, the returning Robotech Expeditionary Force launched a massive final assault to retake Reflex Point. Led by the SDF-4, the expedition utilized new Shadow Fighters and was prepared to use Neutron-S missiles to destroy Reflex Point and the Earth if the mission failed.
At the command of the Invid Regess, the Invid amassed their life forces and abandoned Reflex Point and the Earth. The departing burst of energy wiped out the Neutron-S missiles and many REF ships in the process. Afterwards, the famed singer Yellow Dancer held a farewell concert near the ruins of Reflex Point to celebrate the end of the Third Robotech War.